Role of poly(ADP-ribose) polymerase in sulfur mustard toxicity

被引：37

作者：

Debiak, Malgorzata ^{[1
]}

Kehe, Kai ^{[2
]}

Buerkle, Alexander ^{[1
]}

机构：

[1] Univ Konstanz, Dept Biol, Mol Toxicol Grp, D-78457 Constance, Germany

[2] Bundeswehr Inst Pharmacol & Toxicol, D-80937 Munich, Germany

来源：

TOXICOLOGY | 2009年 / 263卷 / 01期

关键词：

Sulfur mustard; PARP; DNA repair; Cell death; NAD(+); 3-Aminobenzamide; HUMAN EPIDERMAL-KERATINOCYTES; ADP-RIBOSE POLYMERASE; DOUBLE-STRAND BREAKS; HUMAN-LYMPHOCYTES; NAD+ LEVELS; DNA-REPAIR; CELL-DEATH; INHIBITORS; PROTEINS; MICE;

D O I：

10.1016/j.tox.2008.06.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sulfur mustard (SM) is a chemical warfare agent leading to severe blistering of skin and mucosal surfaces, and as a long-term effect, to an increased risk for malignancies. At the molecular level, SM acts as a bifunctional alkylating agent, leading to DNA mono-adducts and di-adducts. This review is focussed on the role of poly(ADP-ribosyl)ation in the cell and tissue responses to SM-induced damage and potential role of inhibitors of poly(ADP-ribosyl)ation as therapeutic agents for SM injury. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：20 / 25

页数：6

共 49 条

[1] Poly (ADP-ribose) polymerase (PARP) is essential for sulfur mustard-induced DNA damage repair, but has no role in DNA ligase activation [J].

Bhat, K. Ramachandra ;

Benton, Betty J. ;

Ray, Radharaman .

JOURNAL OF APPLIED TOXICOLOGY, 2006, 26 (05) :452-457

[2] DNA ligase I is an in vivo substrate of DNA-dependent protein kinase and is activated by phosphorylation in response to DNA double-strand breaks [J].

Bhat, K. Ramachandra ;

Benton, Betty J. ;

Ray, Radharaman .

BIOCHEMISTRY, 2006, 45 (20) :6522-6528

[3]

Bhat KR, 2000, J APPL TOXICOL, V21, pS13

[4] Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase [J].

Bryant, HE ;

Schultz, N ;

Thomas, HD ;

Parker, KM ;

Flower, D ;

Lopez, E ;

Kyle, S ;

Meuth, M ;

Curtin, NJ ;

Helleday, T .

NATURE, 2005, 434 (7035) :913-917

[5] Poly(ADP-ribose) -: The most elaborate metabolite of NAD [J].

Bürkle, A .

FEBS JOURNAL, 2005, 272 (18) :4576-4589

[6]

Casillas RP, 2000, J APPL TOXICOL, V21, pS145

[7] Putative role of proteolysis and inflammatory response in the toxicity of nerve and blister chemical warfare agents: Implications for multi-threat medical countermeasures [J].

Cowan, FM ;

Broomfield, CA ;

Lenz, DE ;

Smith, WJ .

JOURNAL OF APPLIED TOXICOLOGY, 2003, 23 (03) :177-186

[8] An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes [J].

Dillman, JF ;

McGary, KL ;

Schlager, JJ .

TOXICOLOGY IN VITRO, 2004, 18 (05) :593-599

[9] Poly(ADP-ribose) polymerase 1 promotes tumor cell survival by coactivating hypoxia-inducible factor-1-dependent gene expression [J].

Elser, Michael ;

Borsig, Lubor ;

Hassa, Paul O. ;

Erener, Suheda ;

Messner, Simon ;

Valovka, Taras ;

Keller, Stephan ;

Gassmann, Max ;

Hottiger, Michael O. .

MOLECULAR CANCER RESEARCH, 2008, 6 (02) :282-290

[10] Chemical weapons [J].

Evison, D ;

Hinsley, D ;

Rice, P .

BRITISH MEDICAL JOURNAL, 2002, 324 (7333) :332-335

← 1 2 3 4 5 →