Diabetes and the treatment of ischemic stroke

被引：7

作者：

Su, Enming J. ^{[1
]}

Lawrence, Daniel A. ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2022年 / 36卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Stroke; Tissue plasminogen activator; Thrombolysis; Diabetes; TISSUE-PLASMINOGEN ACTIVATOR; BLOOD-BRAIN-BARRIER; SYMPTOMATIC INTRACEREBRAL HEMORRHAGE; GROWTH-FACTOR-CC; PDGF-CC; INTRAVENOUS THROMBOLYSIS; STANDARD TREATMENT; SIGNALING PATHWAY; INFARCT VOLUME; HYPERGLYCEMIA;

D O I：

10.1016/j.jdiacomp.2022.108318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This white paper examines the current challenges for treating ischemic stroke in diabetic patients. The need for a greater understanding of the mechanisms that underlie the relationship between diabetes and the cerebral vascular responses to ischemia is discussed. The critical need to improve the efficacy and safety of thrombolysis is addressed, as is the need for a better characterization the off-target actions of tPA, the only currently approved thrombolytic for the treatment of ischemic stroke.

引用

页数：4

共 83 条

[1] The Leading Causes of Death in the US for 2020
Ahmad, Farida B.
Anderson, Robert N.
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2021, 325 (18): : 1829 - 1830
[2] Association of Admission Blood Glucose and Outcome in Patients Treated With Intravenous Thrombolysis
Ahmed, Niaz
Davalos, Antoni
Eriksson, Niclas
Ford, Gary A.
Glahn, Joerg
Hennerici, Michael
Mikulik, Robert
Kaste, Markku
Lees, Kennedy R.
Lindsberg, Perttu J.
Toni, Danilo
[J]. ARCHIVES OF NEUROLOGY, 2010, 67 (09) : 1123 - 1130
[3] Implementation and outcome of thrombolysis with alteplase 3-4.5 h after an acute stroke: an updated analysis from SITS-ISTR
Ahmed, Niaz
Wahlgren, Nils
Grond, Martin
Hennerici, Michael
Lees, Kennedy R.
Mikulik, Robert
Parsons, Mark
Roine, Risto O.
Toni, Danilo
Ringleb, Peter
[J]. LANCET NEUROLOGY, 2010, 9 (09) : 866 - 874
[4] [Anonymous], 2017, National Diabetes Statistics Report
[5] Diabetes is an independent risk factor for in-hospital mortality from acute spontaneous intracerebral hemorrhage
Arboix, A
Massons, J
García-Eroles, L
Oliveres, M
Targa, C
[J]. DIABETES CARE, 2000, 23 (10) : 1527 - 1532
[6] Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK
Armstead, William M.
Hekierski, Hugh
Pastor, Philip
Yarovoi, Serge
Higazi, Abd Al-Roof
Cines, Douglas B.
[J]. TRANSLATIONAL STROKE RESEARCH, 2019, 10 (01) : 104 - 111
[7] Duration of Diabetes and Risk of Ischemic Stroke The Northern Manhattan Study
Banerjee, Chirantan
Moon, Yeseon P.
Paik, Myunghee C.
Rundek, Tatjana
Mora-McLaughlin, Consuelo
Vieira, Julio R.
Sacco, Ralph L.
Elkind, Mitchell S. V.
[J]. STROKE, 2012, 43 (05) : 1212 - 1217
[8] Tissue plasminogen activator contributes to the late phase of LTP and to synaptic growth in the hippocampal mossy fiber pathway
Baranes, D
Lederfein, D
Huang, YY
Chen, M
Bailey, CH
Kandel, ER
[J]. NEURON, 1998, 21 (04) : 813 - 825
[9] Geographic Distribution of Diagnosed Diabetes in the US A Diabetes Belt
Barker, Lawrence E.
Kirtland, Karen A.
Gregg, Edward W.
Geiss, Linda S.
Thompson, Theodore J.
[J]. AMERICAN JOURNAL OF PREVENTIVE MEDICINE, 2011, 40 (04) : 434 - 439
[10] Role of diabetes in stroke: Recent advances in pathophysiology and clinical management
Bradley, Sian A.
Spring, Kevin J.
Beran, Roy G.
Chatzis, Dimitrios
Killingsworth, Murray C.
Bhaskar, Sonu M. M.
[J]. DIABETES-METABOLISM RESEARCH AND REVIEWS, 2022, 38 (02)

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