Diabetes and the treatment of ischemic stroke

被引：7

作者：

Su, Enming J. ^{[1
]}

Lawrence, Daniel A. ^{[1
,2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Mol & Integrat Physiol, Ann Arbor, MI 48109 USA

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2022年 / 36卷 / 11期

基金：

美国国家卫生研究院;

关键词：

Stroke; Tissue plasminogen activator; Thrombolysis; Diabetes; TISSUE-PLASMINOGEN ACTIVATOR; BLOOD-BRAIN-BARRIER; SYMPTOMATIC INTRACEREBRAL HEMORRHAGE; GROWTH-FACTOR-CC; PDGF-CC; INTRAVENOUS THROMBOLYSIS; STANDARD TREATMENT; SIGNALING PATHWAY; INFARCT VOLUME; HYPERGLYCEMIA;

D O I：

10.1016/j.jdiacomp.2022.108318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This white paper examines the current challenges for treating ischemic stroke in diabetic patients. The need for a greater understanding of the mechanisms that underlie the relationship between diabetes and the cerebral vascular responses to ischemia is discussed. The critical need to improve the efficacy and safety of thrombolysis is addressed, as is the need for a better characterization the off-target actions of tPA, the only currently approved thrombolytic for the treatment of ischemic stroke.

引用

页数：4

共 83 条

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