Supramolecular Hydrogel of a D-Amino Acid Dipeptide for Controlled Drug Release in Vivo

被引：245

作者：

Liang, Gaolin ^{[1
]}

Yang, Zhimou ^{[1
]}

Zhang, Rongjun ^{[2
]}

Li, Lihua ^{[1
]}

Fan, Yijun ^{[2
]}

Kuang, Yi ^{[3
]}

Gao, Yuan ^{[3
]}

Wang, Ting ^{[4
]}

Lu, W. William ^{[4
]}

Xu, Bing ^{[1
,3
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Peoples R China

[2] Jiansu Inst Nucl Med, Wuxi, Jiangsu, Peoples R China

[3] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

[4] Univ Hong Kong, Dept Orthoped & Traumatol, Hong Kong, Peoples R China

来源：

LANGMUIR | 2009年 / 25卷 / 15期

关键词：

SMALL-MOLECULE HYDROGELS; ENZYMATIC FORMATION; INTRACELLULAR HYDROGELATION; DELIVERY; NANOFIBERS;

D O I：

10.1021/la804271d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A supramolecular hydrogel based on D-amino acids, which resists hydrolysis catalyzed by proteinase K and offers long-term biostability, exhibits controlled release in vivo, as proved I-131 the pharmacokinetics of encapsulated I-125 tracers and the SPECT imaging of the hydrogel-encapsulated I tracers. As the first in vivo imaging investigation of the drug release properties of the supramolecular hydrogel, isotope encapsulation serves as a valid, useful assay for characterizing the controlled release properties of supramolecular hydrogels in vivo. Our results indicate that supramolecular hydrogels promise new biomaterials for controlled drug release.

引用

页码：8419 / 8422

页数：4

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