A new framework for the cycloaromatization of enediynes under mild conditions.

被引：15

作者：

Semmelhack, MF

Gu, YS

Ho, DM

机构：

[1] Department of Chemistry, Princeton University, Princeton

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 32期

关键词：

D O I：

10.1016/S0040-4039(97)01263-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An enediyne unit in a bicyclo[8.3.0] framework with a trans ring fusion has been designed, synthesized, and evaluated as a new functional model for the enediyne toxins. The cycloaromatization reaction proceeds with a half-life time of 13-14 hr at 25 degrees C. (C) 1997 Elsevier Science Ltd.

引用

收藏

页码：5583 / 5586

页数：4

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