t-BuOK-mediated hydrophosphination of functionalized alkenes:: a novel synthesis of chiral P,N- and P,P-ligands

被引:54
作者
Bunlaksananusorn, T [1 ]
Knochel, P [1 ]
机构
[1] Univ Munich, Dept Chem, D-81377 Munich, Germany
关键词
D O I
10.1021/jo030383u
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A novel synthesis of effective chiral P,N- and P,P-ligands has been developed by using a t-BuOK-mediated hydrophosphination of chiral alkenylpyridines and alkenylphosphine oxides. Ir complexes of chiral P,N-ligrands 1 and 3 gave high enantioselectivities for the hydrogenation of (Z)-alpha(acetamido)cinnamate 25 and (E)-1,2-diphenylpropene leading to the hydrogenated products with up to 97% ee.
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页码:4595 / 4601
页数:7
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