Physicochemical modelling of cell signalling pathways

被引：406

作者：

Aldridge, Bree B.

Burke, John M.

Lauffenburger, Douglas A.

Sorger, Peter K.

机构：

[1] MIT, Ctr Cell Decis Proc, Dept Biol Engn, Cambridge, MA 02139 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

NATURE CELL BIOLOGY | 2006年 / 8卷 / 11期

关键词：

D O I：

10.1038/ncb1497

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Physicochemical modelling of signal transduction links fundamental chemical and physical principles, prior knowledge about regulatory pathways, and experimental data of various types to create powerful tools for formalizing and extending traditional molecular and cellular biology.

引用

页码：1195 / 1203

页数：9

共 45 条

[1] Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour
Aldridge, B. B.
Haller, G.
Sorger, P. K.
Lauffenburger, D. A.
[J]. IEE PROCEEDINGS SYSTEMS BIOLOGY, 2006, 153 (06): : 425 - 432
[2] Tools for kinetic modeling of biochemical networks
Alves, Rui
Antunes, Fernando
Salvador, Armindo
[J]. NATURE BIOTECHNOLOGY, 2006, 24 (06) : 667 - 672
[3] [Anonymous], CURR BIOINFORM
[4] [Anonymous], SYSTEM MODELING CELL
[5] Verification, validation and accreditation of simulation models
Balci, O
[J]. PROCEEDINGS OF THE 1997 WINTER SIMULATION CONFERENCE, 1997, : 135 - 141
[6] Mathematical modeling reveals threshold mechanism in CD95-induced apoptosis
Bentele, M
Lavrik, I
Ulrich, M
Stösser, S
Heermann, DW
Kalthoff, H
Krammer, PH
Eils, R
[J]. JOURNAL OF CELL BIOLOGY, 2004, 166 (06) : 839 - 851
[7] MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
Bhalla, US
Ram, PT
Iyengar, R
[J]. SCIENCE, 2002, 297 (5583) : 1018 - 1023
[8] A network model of early events in epidermal growth factor receptor signaling that accounts for combinatorial complexity
Blinov, ML
Faeder, JR
Goldstein, B
Hlavacek, WS
[J]. BIOSYSTEMS, 2006, 83 (2-3) : 136 - 151
[9] A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks
Conzelmann, H
Saez-Rodriguez, J
Sauter, T
Kholodenko, BN
Gilles, ED
[J]. BMC BIOINFORMATICS, 2006, 7 (1)
[10] Quantitative fluorescent speckle Microscopy of cytoskeleton dynamics
Danuser, Gaudenz
Waterman-Storer, Clare M.
[J]. ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, 2006, 35 : 361 - 387

← 1 2 3 4 5 →