Long non-coding RNAs: A new frontier in the study of human diseases

被引：1095

作者：

Shi, Xuefei ^{[1
]}

Sun, Ming ^{[2
]}

Liu, Hongbing ^{[1
]}

Yao, Yanwen ^{[1
]}

Song, Yong ^{[1
]}

机构：

[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Resp Med, Nanjing 210002, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Biochem & Mol Biol, Nanjing, Jiangsu, Peoples R China

来源：

CANCER LETTERS | 2013年 / 339卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Long non-coding RNAs; Human diseases; Mechanism; PROSTATE-SPECIFIC GENE; TUMOR-SUPPRESSOR GENE; POOR-PROGNOSIS; CANCER CELLS; MESSENGER-RNA; BC200; RNA; H19; GENE; XIST RNA; EXPRESSION; IDENTIFICATION;

D O I：

10.1016/j.canlet.2013.06.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the development of whole genome and transcriptome sequencing technologies, long noncoding RNAs (lncRNAs) have received increased attention. Multiple studies indicate that lncRNAs act not only as the intermediary between DNA and protein but also as important protagonists of cellular functions. LncRNAs can regulate gene expression in many ways, including chromosome remodeling, transcription and post-transcriptional processing. Moreover, the dysregulation of IncRNAs has increasingly been linked to many human diseases, especially in cancers. Here, we reviewed the rapidly advancing field of lncRNAs and described the relationship between the dysregulation of lncRNAs and human diseases, highlighting the specific roles of lncRNAs in human diseases. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：159 / 166

页数：8

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