Bioavailability of magnetic nanoparticles to the brain

被引：11

作者：

Huang, Bor-Ren ^{[1
]}

Chen, Pin-Yuan ^{[1
,6
]}

Huang, Chiung-Yin ^{[1
]}

Jung, Shih-Ming ^{[3
]}

Ma, Yunn-Hwa ^{[4
]}

Wu, Tony ^{[5
]}

Chen, Jyh-Ping ^{[2
]}

Wei, Kuo-Chen ^{[1
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurosurg, Tao Yuan 333, Taiwan

[2] Chang Gung Univ, Coll Med, Dept Chem & Mat Engn, Tao Yuan 333, Taiwan

[3] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Pathol, Tao Yuan 333, Taiwan

[4] Chang Gung Univ, Coll Med, Dept Physiol & Pharmacol, Tao Yuan 333, Taiwan

[5] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol, Tao Yuan 333, Taiwan

[6] Chang Gung Univ, Grad Inst Biomed Sci, Tao Yuan 333, Taiwan

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2009年 / 321卷 / 10期

关键词：

Nanoparticle; Tissue distribution; Magnetics; Glioma; Drug carrier; SYSTEM; BIODISTRIBUTION; DELIVERY; GROWTH;

D O I：

10.1016/j.jmmm.2009.02.095

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

This study investigates the bioavailability of carboxymethyl dextran-coated magnetic nanoparticles (CMD-MNP) to the brain. The cytotoxicity of CMD-MNP was assessed by co-culture with C6, a rat glioma cell line. To investigate the effects of an external magnetic field on the biodistribution of nanoparticles in a rat model, a magnet of 0.3 Tesla was applied externally over the cranium and the particles injected via the external jugular vein. Nanoparticles were also injected into rats implanted with C6 tumor cells. Staining of histological samples with Prussian blue to detect iron particles revealed that the external magnetic field enhanced the aggregation of nanoparticles in the rat brain; this enhancement was even more pronounced in the tumor region. (C) 2009 Published by Elsevier B.V.

引用

页码：1604 / 1609

页数：6

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