Wnt/β-catenin signaling activates nephronectin expression in osteoblasts

被引：31

作者：

Ikehata, Mikiko ^{[1
,2
]}

Yamada, Atsushi ^{[1
]}

Morimura, Naoko ^{[3
]}

Itose, Masakatsu ^{[1
,4
]}

Suzawa, Tetsuo ^{[1
]}

Shirota, Tatsuo ^{[4
]}

Chikazu, Daichi ^{[2
]}

Kamijo, Ryutaro ^{[1
]}

机构：

[1] Showa Univ, Sch Dent, Dept Biochem, 1-5-8 Hatanodai, Shinagawa, Tokyo 1428555, Japan

[2] Tokyo Med Univ, Dept Oral & Maxillofacial Surg, Tokyo, Japan

[3] Shiga Univ Med Sci, Dept Integrat Physiol, Otsu, Shiga, Japan

[4] Showa Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Tokyo, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2017年 / 484卷 / 02期

基金：

日本学术振兴会;

关键词：

Nephronectin; Wnt3a; beta-catenin; PROTEIN NEPHRONECTIN; STEM-CELLS; RECEPTORS; MOLECULE; POEM;

D O I：

10.1016/j.bbrc.2017.01.053

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nephronectin (Npnt), an extracellular matrix protein, is considered to play critical roles as an adhesion molecule in the development and functions of various organs and tissues, such as the kidneys and bone. In the present study, we found that Wnt3a strongly enhanced Npnt mRNA expression in osteoblast-like MC3T3-E1 cells, while it also induced an increase in Npnt gene expression in both time- and dose-dependent manners via the Wnt/beta-catenin signaling pathway. These results suggest novel mechanisms for Wnt3a-induced osteoblast proliferation and cell survival via Npnt gene expression. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：231 / 234

页数：4

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