Medical progress: Carcinoma of the anal canal.

被引:289
作者
Ryan, DP
Compton, CC
Mayer, RJ
机构
[1] Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Div Hematol & Oncol, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Dept Med, Boston, MA 02114 USA
[4] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
[5] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[6] Harvard Univ, Sch Med, Boston, MA USA
关键词
D O I
10.1056/NEJM200003163421107
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Despite the rarity of carcinoma of the anal canal, remarkable progress has been achieved during the past 30 years in understanding its pathogenesis and improving treatment. Largely because of the rigorous collection of data and the treatment of patients in clinical trials, it is now widely accepted that the majority of cases are caused by human papillomavirus and can be cured by combination therapy. Concomitant treatment with external-beam radiation therapy and chemotherapy with fluorouracil and mitomycin represents the standard approach to combination treatment. Appropriate cytologic screening of high-risk populations and the integration of platinum compounds into treatment regimens will most likely reduce mortality from this disorder even further.
引用
收藏
页码:792 / 800
页数:9
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