Experimental Bacteriophage Therapy Increases Survival of Galleria mellonella Larvae Infected with Clinically Relevant Strains of the Burkholderia cepacia Complex

被引：69

作者：

Seed, Kimberley D. ^{[1
]}

Dennis, Jonathan J. ^{[1
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2009年 / 53卷 / 05期

关键词：

CYSTIC-FIBROSIS; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; PHAGE THERAPY; MODEL HOST; MICE; PATHOGENESIS; IDENTIFICATION; EPIDEMIOLOGY; CANDIDATE;

D O I：

10.1128/AAC.01166-08

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Burkholderia cepacia complex (BCC) is a group of bacterial pathogens that are highly antibiotic resistant and associated with debilitating respiratory infections. Although bacteriophages of the BCC have been isolated and characterized, no studies have yet examined phage therapy against the BCC in vivo. In a caterpillar infection model, we show that BCC phage therapy is an alternative treatment possibility and is highly effective under specific conditions.

引用

页码：2205 / 2208

页数：4

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