Protein isoprenylation: the fat of the matter

被引：55

作者：

Crowell, Dring N. ^{[1
]}

Huizinga, David H. ^{[2
]}

机构：

[1] Idaho State Univ, Dept Biol Sci, Pocatello, ID 83209 USA

[2] Indiana Univ Purdue Univ, Dept Biol, Indianapolis, IN 46202 USA

来源：

TRENDS IN PLANT SCIENCE | 2009年 / 14卷 / 03期

基金：

美国国家科学基金会;

关键词：

ALPHA-CARBOXYL METHYLTRANSFERASE; AUXIN-RESPONSIVE GENE; GTP-BINDING PROTEIN; ABSCISIC-ACID; PLASMA-MEMBRANE; DISEASE RESISTANCE; GAMMA-SUBUNITS; CELL EXPANSION; SMALL GTPASES; ROP2; GTPASE;

D O I：

10.1016/j.tplants.2008.12.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Protein isoprenylation refers to the covalent attachment of a 15-carbon farnesyl or 20-carbon geranylgeranyl moiety to a cysteine residue at or near the carboxyl terminus. This post-translational lipid modification, which mediates protein-membrane and protein-protein interactions, is necessary for normal control of abscisic acid and auxin signaling, meristem development, and other fundamental processes. Recent studies have also revealed roles for protein isoprenylation in cytokinin biosynthesis and innate immunity. Most isoprenylated proteins are further modified by carboxyl terminal proteolysis and methylation and, collectively, these modifications are necessary for the targeting and function of isoprenylated proteins.

引用

页码：163 / 170

页数：8

共 79 条

[1] Both abscisic acid (ABA)-dependent and ABA-independent pathways govern the induction of NCED3, AAO3 and ABA1 in response to salt stress [J].

Barrero, Jose Maria ;

Rodriguez, Pedro L. ;

Quesada, Victor ;

Piqueras, Pedro ;

Ponce, Maria Rosa ;

Micol, Jose Luis .

PLANT CELL AND ENVIRONMENT, 2006, 29 (10) :2000-2008

[2]

BIERMANN BJ, 1994, J BIOL CHEM, V269, P25251

[3] Characterization of a small GTP-binding protein of the rab 5 family in Mesembryanthemum crystallinum with increased level of expression during early salt stress [J].

Bolte, S ;

Schiene, K ;

Dietz, KJ .

PLANT MOLECULAR BIOLOGY, 2000, 42 (06) :923-936

[4] The N-myristoylated Rab-GTPase m-Rabmc is involved in post-Golgi trafficking events to the lytic vacuole in plant cells [J].

Bolte, S ;

Brown, S ;

Satiat-Jeunemaitre, B .

JOURNAL OF CELL SCIENCE, 2004, 117 (06) :943-954

[5] Farnesylation is involved in meristem organization in Arabidopsis [J].

Bonetta, D ;

Bayliss, P ;

Sun, S ;

Sage, T ;

McCourt, P .

PLANTA, 2000, 211 (02) :182-190

[6] The Arabidopsis AtSTE24 is a CAAX protease with broad substrate specificity [J].

Bracha, K ;

Lavy, M ;

Yalovsky, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (33) :29856-29864

[7] Functional analysis of Arabidopsis postprenylation CaaX processing enzymes and their function in subcellular protein targeting [J].

Bracha-Drori, Keren ;

Shichrur, Keren ;

Lubetzky, Tsofnat Cohen ;

Yalovsky, Shaul .

PLANT PHYSIOLOGY, 2008, 148 (01) :119-131

[8] The ABSCISIC ACID INSENSITIVE 3 (ABI3) gene is modulated by farnesylation and is involved in auxin signaling and lateral root development in Arabidopsis [J].

Brady, SM ;

Sarkar, SF ;

Bonetta, D ;

McCourt, P .

PLANT JOURNAL, 2003, 34 (01) :67-75

[9] AtFACE-2, a functional prenylated protein protease from Arabidopsis thaliana related to mammalian Ras-converting enzymes [J].

Cadiñanos, J ;

Varela, I ;

Mandel, DA ;

Schmidt, WK ;

Díaz-Perales, A ;

López-Otín, C ;

Freije, JMP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) :42091-42097

[10] Efficient prenylation by a plant geranylgeranyl-transferase-I requires a functional CaaL box motif and a proximal polybasic domain [J].

Caldelari, D ;

Sternberg, H ;

Rodríguez-Concepción, M ;

Gruissem, W ;

Yalovsky, S .

PLANT PHYSIOLOGY, 2001, 126 (04) :1416-1429

← 1 2 3 4 5 6 7 8 →