Protein isoprenylation: the fat of the matter

被引：55

作者：

Crowell, Dring N. ^{[1
]}

Huizinga, David H. ^{[2
]}

机构：

[1] Idaho State Univ, Dept Biol Sci, Pocatello, ID 83209 USA

[2] Indiana Univ Purdue Univ, Dept Biol, Indianapolis, IN 46202 USA

来源：

TRENDS IN PLANT SCIENCE | 2009年 / 14卷 / 03期

基金：

美国国家科学基金会;

关键词：

ALPHA-CARBOXYL METHYLTRANSFERASE; AUXIN-RESPONSIVE GENE; GTP-BINDING PROTEIN; ABSCISIC-ACID; PLASMA-MEMBRANE; DISEASE RESISTANCE; GAMMA-SUBUNITS; CELL EXPANSION; SMALL GTPASES; ROP2; GTPASE;

D O I：

10.1016/j.tplants.2008.12.001

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Protein isoprenylation refers to the covalent attachment of a 15-carbon farnesyl or 20-carbon geranylgeranyl moiety to a cysteine residue at or near the carboxyl terminus. This post-translational lipid modification, which mediates protein-membrane and protein-protein interactions, is necessary for normal control of abscisic acid and auxin signaling, meristem development, and other fundamental processes. Recent studies have also revealed roles for protein isoprenylation in cytokinin biosynthesis and innate immunity. Most isoprenylated proteins are further modified by carboxyl terminal proteolysis and methylation and, collectively, these modifications are necessary for the targeting and function of isoprenylated proteins.

引用

页码：163 / 170

页数：8

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