E pluribus unum:: towards a universal mechanism for spindle assembly

被引：86

作者：

Wadsworth, P ^{[1
]}

Khodjakov, A

机构：

[1] Univ Massachusetts, Dept Biol, Morrill Sci Ctr, Amherst, MA 01003 USA

[2] New York State Dept Hlth, Wadsworth Ctr Labs & Res, Albany, NY 12201 USA

来源：

TRENDS IN CELL BIOLOGY | 2004年 / 14卷 / 08期

关键词：

D O I：

10.1016/j.tcb.2004.07.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent data have revealed that the mitotic spindle might form by centrosome-independent mechanisms, even in centrosome-containing cells. This suggests that spindle assembly might proceed by a generally conserved acentrosomal mechanism in all higher eukaryotes, regardless of the presence of centrosomes. Thus, what is the role of centrosomes in mitosis? We propose that these organelles are needed to generate radial arrays of microtubules that integrate preassembled (by centrosome-independent mechanisms) spindle components into a common spindle and orientate the spindle within malleable animal cells.

引用

收藏

页码：413 / 419

页数：7

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