Benzophenanthridine alkaloids from Zanthoxylum nitidum (ROXB.) DC, and their analgesic and anti-inflammatory activities

被引：115

作者：

Hu, Jiang

Zhang, Wei-Dong ^{[1
]}

Liu, Run-Hui

Zhang, Chuan

Shen, Yun-Heng

Li, Hui-Liang

Liang, Ming-Jin

Xu, Xi-Ke

机构：

[1] Second Mil Med Univ, Sch Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2006年 / 3卷 / 09期

关键词：

D O I：

10.1002/cbdv.200690108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven benzophenanthridine alkaloids, 1-7, were isolated from the roots of Zanthoxylum nitidum. Among them, two novel alkaloids, named (R)-8-[(R)-1-hydroxyethyl]dihydrochelerythrine (1) and 8-methoxynorchelerythrine (2), were structurally identified as new compounds on the basis of the spectroscopic analysis. Bioactivity evaluation showed that nitidine (3), dihydrochelerythrine (4), oxyavicine (5), 8-methoxychelerythrine (6), and 8-hydroxydihydrochelerythrine (7) exhibit comparable analgesic and anti-inflammatory effects as hydrocortisone.

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页码：990 / 995

页数：6

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