Solid-phase synthesis of α-sulfonylamino amide derivatives based on Ugi-type condensation reaction using sulfonamides as amine input

被引：13

作者：

Campian, E ^{[1
]}

Lou, BL ^{[1
]}

Saneii, H ^{[1
]}

机构：

[1] Adv SynTech, LLC, Louisville, KY 40299 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 47期

关键词：

solid-phase synthesis; multi-component condensation reaction; sulfonamide;

D O I：

10.1016/S0040-4039(02)02085-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A method for solid-phase synthesis of a-sulfonylamino amides has been developed, which relies on a new Ugi-type 4-component condensation reaction involving arylsulfonamides as an amine input followed by removal of the acid moiety under the basic conditions. Either polymer-bound sulfonamides or carboxylic acids can be used in this reaction to afford structurally diverse products with good purity and in moderate to excellent yield. (C) 2002 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8467 / 8470

页数：4

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