Isolation of parapoxvirus from a cow treated with interferon-γ

被引：18

作者：

Sentsui, H ^{[1
]}

Murakami, K ^{[1
]}

Inoshima, Y ^{[1
]}

Shibahara, T ^{[1
]}

Yokomizo, Y ^{[1
]}

机构：

[1] Natl Inst Anim Hlth, Tsukuba, Ibaraki 3050856, Japan

来源：

VETERINARY MICROBIOLOGY | 1999年 / 70卷 / 3-4期

关键词：

cattle-viruses; interferon-gamma; parapoxvirus; persistent infection; peripheral blood leukocytes;

D O I：

10.1016/S0378-1135(99)00138-8

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A virus was isolated from peripheral blood leukocytes of a cow which was kept in an isolated pen after it was injected with recombinant bovine interferon-gamma. The virus was identified as a member of genus Parapoxvirus in the family Poxviridae on the basis of electron microscopic observations and serological tests. Parapoxvirus has seldom been isolated other than from papular lesions, the characteristic sign of parapoxvirus infection. This is the first report of parapoxvirus isolation from the peripheral blood of a cow without any clinical signs. These results show that parapoxviruses are capable of causing persistent infection in cattle without clinical signs and can be activated by stress factors that induce modification of immune reactions. Relationships between the isolated virus and other parapoxviruses isolated previously from cattle in Japan were investigated and discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：143 / 152

页数：10

共 26 条

[1]

Davis W. C., 1990, Monographs in Animal Immunology, V1, P47

[2] Analysis of monoclonal antibodies specific for the gamma delta TcR [J].