Ordered mesoporous materials in the context of drug delivery systems and bone tissue engineering

被引：424

作者：

Vallet-Regi, Maria ^{[1
]}

机构：

[1] UCM, Fac Farm, Dept Quim Inorgan & Bioinorgan, Madrid 28040, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2006年 / 12卷 / 23期

关键词：

bioceramics; bone tissue regeneration; drug delivery; mesoporous materials;

D O I：

10.1002/chem.200600226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chemistry, materials science and medicine are research areas that converge in the field of drug delivery systems and tissue engineering. This paper tries to introduce an example of such an interaction, aimed at solving health issues within the world of biomaterials. Ordered mesoporous materials can be loaded with different organic molecules that would be released afterwards, in a controlled fashion, inside a living body. These materials can also react with the body fluids giving rise to carbonated nanoapatite particles as the products of such a chemical interaction; these particles, equivalent to biological apatites, enable the regeneration of bone tissue.

引用

页码：5934 / 5943

页数：10

共 84 条

[51] Photocontrolled reversible release of guest molecules from coumarin-modified mesoporous silica [J].

Mal, NK ;

Fujiwara, M ;

Tanaka, Y .

NATURE, 2003, 421 (6921) :350-353

[52] Biocompatibility and in vivo gentamicin release from bioactive sol-gel glass implants [J].

Meseguer-Olmo, L ;

Ros-Nicolás, MJ ;

Clavel-Sainz, M ;

Vicente-Ortega, V ;

Alcaraz-Baños, M ;

Lax-Pérez, A ;

Arcos, D ;

Ragel, CV ;

Vallet-Regí, M .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 2002, 61 (03) :458-465

[53] MCM-41 organic modification as drug delivery rate regulator [J].

Muñoz, B ;

Rámila, A ;

Pérez-Pariente, J ;

Díaz, I ;

Vallet-Regí, M .

CHEMISTRY OF MATERIALS, 2003, 15 (02) :500-503

[54] In vitro release of gentamicin from OHAp/PEMA/PMMA samples [J].

Padilla, S ;

del Real, RP ;

Vallet-Regí, M .

JOURNAL OF CONTROLLED RELEASE, 2002, 83 (03) :343-352

[55] Drug release and in vitro assays of bioactive polymer/glass mixtures [J].

Rámila, A ;

Del Real, RP ;

Marcos, R ;

Horcajada, P ;

Vallet-Regí, M .

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2003, 26 (1-3) :1195-1198

[56] Mesoporous MCM-41 as drug host system [J].

Rámila, A ;

Muñoz, B ;

Pérez-Pariente, J ;

Vallet-Regí, M .

JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 2003, 26 (1-3) :1199-1202

[57] Direct imaging of the pores and cages of three-dimensional mesoporous materials [J].

Sakamoto, Y ;

Kaneda, M ;

Terasaki, O ;

Zhao, DY ;

Kim, JM ;

Stucky, G ;

Shim, HJ ;

Ryoo, R .

NATURE, 2000, 408 (6811) :449-453

[58] Refinement of ibuprofen at 100 K by single-crystal pulsed neutron diffraction [J].

Shankland, N ;

Wilson, CC ;

Florence, AJ ;

Cox, PJ .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1997, 53 :951-954

[59] Magnetic nanotubes for magnetic-field-assisted bioseparation, biointeraction, and drug delivery [J].

Son, SJ ;

Reichel, J ;

He, B ;

Schuchman, M ;

Lee, SB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (20) :7316-7317

[60]

Stein A, 2000, ADV MATER, V12, P1403, DOI 10.1002/1521-4095(200010)12:19<1403::AID-ADMA1403>3.0.CO

← 1 2 3 4 5 6 7 8 9 →