Synthesis of 7-deaza-8-bromo cyclic adenosine 5'-diphosphate ribose: The first hydrolysis resistant antagonist at the cADPR receptor

被引:15
作者
Bailey, VC
Sethi, JK
Galione, A
Potter, BVL
机构
[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND
[2] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND
关键词
D O I
10.1039/a700336f
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
7-Deaza-8-bromo cyclic adenosine 5'-diphosphate ribose is synthesised from 7-deazaadenosine via 7-deaza-8-bromo nicotinamide adenine dinucleotide; it is both a more potent antagonist than the 8-bromo derivative and has the advantage of chemical and enzymatic hydrolytic stability.
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页码:695 / 696
页数:2
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