CHEMOENZYMATIC SYNTHESIS OF ANALOGS OF THE 2ND-MESSENGER CANDIDATE CYCLIC ADENOSINE 5'-DIPHOSPHATE RIBOSE

被引：39

作者：

ASHAMU, GA

GALIONE, A

POTTER, BVL

机构：

[1] UNIV BATH,SCH PHARM & PHARMACOL,DEPT MED CHEM,BATH BA2 7AY,AVON,ENGLAND

[2] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 13期

关键词：

D O I：

10.1039/c39950001359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A broad substrate specificity for adenosine 5'-diphosphate ribosyl cyclase is demonstrated by cyclisation of ribose- and purine-modified nicotinamide adenine dinucleotide analogues to mimics of cyclic adenosine 5'-diphosphate ribose, generating a straightforward route for structural modification of this important Ca2+-mobilising nucleotide.

引用

收藏

页码：1359 / 1360

页数：2

相关论文

共 15 条

[1]

CLAPPER DL, 1987, J BIOL CHEM, V262, P9561

[2] CA-2+-INDUCED CA-2+ RELEASE AND ITS MODULATION BY CYCLIC ADP-RIBOSE [J].

GALIONE, A .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (08) :304-306

[3] CGMP MOBILIZES INTRACELLULAR CA2+ IN SEA-URCHIN EGGS BY STIMULATING CYCLIC ADP-RIBOSE SYNTHESIS [J].

GALIONE, A ;

WHITE, A ;

WILLMOTT, N ;

TURNER, M ;

POTTER, BVL ;

WATSON, SP .

NATURE, 1993, 365 (6445) :456-459

[4]

Galione Antony, 1994, Trends in Cell Biology, V4, P431, DOI 10.1016/0962-8924(94)90104-X

[5]

GRAEFF RM, 1994, J BIOL CHEM, V269, P30260

[6] CYCLIC ADP-RIBOSE - SYNTHESIS AND STRUCTURAL ASSIGNMENT [J].

GU, QM ;

SIH, CJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (17) :7481-7486

[7] CODEHYDROGENASES .3. A SYNTHESIS OF DIPHOSPHOPYRIDINE NUCLEOTIDE (COZYMASE), AND SOME OBSERVATIONS ON THE SYNTHESIS OF TRIPHOSPHOPYRIDINE NUCLEOTIDE [J].

HUGHES, NA ;

KENNER, GW ;

TODD, A .

JOURNAL OF THE CHEMICAL SOCIETY, 1957, (AUG) :3733-3738

[8] POSITION OF CYCLIZATION IN CYCLIC ADP-RIBOSE [J].

KIM, H ;

JACOBSON, EL ;

JACOBSON, MK .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 194 (03) :1143-1147

[9] ADP-RIBOSYL CYCLASE - AN ENZYME THAT CYCLIZES NAD+ INTO A CALCIUM-MOBILIZING METABOLITE [J].

LEE, HC ;

AARHUS, R .

CELL REGULATION, 1991, 2 (03) :203-209

[10] THE CRYSTAL-STRUCTURE OF CYCLIC ADP-RIBOSE [J].

LEE, HC ;

AARHUS, R ;

LEVITT, D .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (03) :143-144