Aerosol measles vaccination in macaques:: Preclinical studies of immune responses and safety

被引：29

作者：

de Swart, Rik L.

Kuiken, Thijs

Fernandez-de Castro, Jorge

Papania, Mark J.

Bennett, John V.

Valdespino, Jose L.

Minor, Phil

Witham, Clyde L.

Yuksel, Selma

Vos, Helma

van Amerongen, Geert

Osterhaus, Albert D. M. E.

机构：

[1] Erasmus MC, Postgrad Sch Mol Med, Dept Virol, NL-3015 GE Rotterdam, Netherlands

[2] Natl Publ Hlth Inst, Cuernavaca, Morelos, Mexico

[3] Emory Univ, Atlanta, GA 30322 USA

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

[5] Natl Inst Biol Stand & Controls, S Mimms, Herts, England

[6] Dura Pharmaceut, San Diego, CA USA

来源：

VACCINE | 2006年 / 24卷 / 40-41期

关键词：

aerosol; nebulized; measles; Edmonston-Zagreb; non-human primates; virus neutralization; immunosuppression; pathology; histology;

D O I：

10.1016/j.vaccine.2006.05.125

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The comparative efficacy and safety of measles vaccination via the aerosol route versus subcutaneous injection has not been fully resolved. We vaccinated cynomolgus monkeys (Macacafascicularis) with the live-attenuated Edmonston-Zagreb measles virus (MV) vaccine and compared different routes of administration in the immunocompetent and the immunocompromised host. Immunogenicity and protective efficacy of aerosol vaccination using devices similar to those previously used in humans were comparable to those in animals vaccinated by injection. No evidence for a safety hazard associated with the route of vaccination was detected. The results of this study support further clinical evaluation of aerosol vaccination for measles. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6424 / 6436

页数：13

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