Autophagy in Antimicrobial Immunity

被引：383

作者：

Gomes, Ligia C. ^{[1
]}

Dikic, Ivan ^{[1
,2
]}

机构：

[1] Goethe Univ Frankfurt, Buchmann Inst Mol Life Sci BMLS, D-60438 Frankfurt, Germany

[2] Goethe Univ Frankfurt, Sch Med, Inst Biochem 2, D-60590 Frankfurt, Germany

来源：

MOLECULAR CELL | 2014年 / 54卷 / 02期

基金：

欧洲研究理事会;

关键词：

UNCONVENTIONAL SECRETION; CELLULAR AUTOPHAGY; UBIQUITIN; PROTEIN; SALMONELLA; BACTERIA; LISTERIA; CELLS; PHOSPHORYLATION; INFECTION;

D O I：

10.1016/j.molcel.2014.03.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Autophagy plays a key role in cellular homeostasis, responding to various environmental stresses. In particular, pathogen invasion leads to rapid induction of autophagy, which is critical for both innate and adaptive immune responses. In this review, we focus on the emerging molecular mechanisms of pathogen elimination by autophagy (a process known as xenophagy) and on the strategies developed by pathogens to subvert autophagy. We also address other functions of autophagy proteins in restricting pathogen invasion, independent of the formation of a canonical double-membrane autophagosome.

引用

页码：224 / 233

页数：10

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