Effects of exercise training on mortality in patients with coronary heart disease

被引:24
作者
Erbs, Sandra [1 ]
Linke, Axel [1 ]
Hambrecht, Rainer [1 ]
机构
[1] Univ Leipzig, Ctr Heart, Dept Internal Med Cardiol, D-04289 Leipzig, Germany
关键词
collaterals; coronary heart disease; endothelial dysfunction; enclothelial nitric oxide synthase; enclothelial progenitor cells; exercise training; mortality;
D O I
10.1097/00019501-200605000-00003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Endothelial dysfunction not only precedes the development of significant coronary artery stenosis, it has also been identified as a general phenomenon predicting future cardiovascular events in patients who are at risk. As regular physical activity as a part of a multifactorial intervention has been shown to affect symptoms beneficially, increase myocardial perfusion and - most importantly - reduce mortality in patients with coronary heart disease or myocardial infarction, this review will elucidate potential mechanisms responsible for the improvement in survival as a result of regular physical activity. The importance of exercise training-mediated regression of coronary stenosis, collateral formation, correction of endothelial dysfunction including the adaptation at the molecular level, as well as vasculogenesis will be discussed as possible underlying key players, and their potential contribution to the training-induced survival benefit in patients with coronary heart disease will be critically evaluated.
引用
收藏
页码:219 / 225
页数:7
相关论文
共 42 条
[1]   Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease [J].
Adams, V ;
Linke, A ;
Kränkel, N ;
Erbs, S ;
Gielen, S ;
Möbius-Winkler, S ;
Gummert, JF ;
Mohr, FW ;
Schuler, G ;
Hambrecht, R .
CIRCULATION, 2005, 111 (05) :555-562
[2]   Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia [J].
Adams, V ;
Lenk, K ;
Linke, A ;
Lenz, D ;
Erbs, S ;
Sandri, M ;
Tarnok, A ;
Gielen, S ;
Emmrich, F ;
Schuler, G ;
Hambrecht, R .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (04) :684-690
[3]   Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].
Asahara, T ;
Masuda, H ;
Takahashi, T ;
Kalka, C ;
Pastore, C ;
Silver, M ;
Kearne, M ;
Magner, M ;
Isner, JM .
CIRCULATION RESEARCH, 1999, 85 (03) :221-228
[4]  
Belardinelli R, 1998, CIRCULATION, V97, P553
[5]   Exercise training intervention after coronary angioplasty: The ETICA trial [J].
Belardinelli, R ;
Paolini, I ;
Cianci, G ;
Piva, R ;
Georgiou, D ;
Purcaro, A .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (07) :1891-1900
[6]  
Chamberlain DA, 1997, LANCET, V350, P461
[7]   Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation [J].
Crosby, JR ;
Kaminski, WE ;
Schatteman, G ;
Martin, PJ ;
Raines, EW ;
Seifert, RA ;
Bowen-Pope, DF .
CIRCULATION RESEARCH, 2000, 87 (09) :728-730
[8]   Exercise and cardiovascular health - Get active to "AKTivate" your endothelial nitric oxide synthase [J].
Dimmeler, S ;
Zeiher, AM .
CIRCULATION, 2003, 107 (25) :3118-3120
[9]   Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction [J].
Erbs, S ;
Baither, Y ;
Linke, A ;
Adams, V ;
Shu, YW ;
Lenk, K ;
Gielen, S ;
Dilz, R ;
Schuler, G ;
Hambrecht, R .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (10) :1814-1819
[10]   Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase [J].
Fleming, I ;
Busse, R .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2003, 284 (01) :R1-R12