Preparation and characteristics of hydroxypropyl-β-cyclodextrin polymeric nanocapsules loading nimodipine

被引：41

作者：

Du, Yong-Zhong ^{[1
]}

Xu, Jia-Guo ^{[1
]}

Wang, Ling ^{[1
]}

Yuan, Hong ^{[1
]}

Hu, Fu-Qiang ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

EUROPEAN POLYMER JOURNAL | 2009年 / 45卷 / 05期

关键词：

Hydroxypropyl-beta-cyclodextrin; Polymeric nanocapsules; Nimodipine; Polyaddition; In vitro drug release; PHARMACEUTICAL APPLICATION; INCLUSION COMPLEXES; NANOPARTICLES; PHOTODEGRADATION; MICROSPHERES; ALPHA;

D O I：

10.1016/j.eurpolymj.2009.01.031

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Nimodipine loaded hydroxypropyl-beta-cyclodextrin polymeric nanocapsules were prepared by interfacial polyaddition of hydroxypropyl-beta-cyclodextrin and isophorone diisocyante in a miniemulsion system. The effects of ultrasonicate times on the preparation of miniemulsion, the total amount of hydroxypropyl-beta-cyclodextrin and isophorone diisocyante, and the molar ratio of isophorone diisocyante to hydroxypropyl-beta-cyclodextrin on the capsule size and drug release behavior from capsule were investigated. The chitosan based polymeric nanocapsules were prepared as a control to study the effect of hydroxypropyl-beta-cyclodextrin molecules in capsule matrix on the drug release. The results indicated that the droplet size of miniemulsion and capsule size decreased with increasing sonicate times. When the total amount of hydroxypropyl-beta-cyclodextrin and isophorone diisocyante and, the molar ratio of isophorone diisocyante to hydroxypropyl-beta-cyclodextrin were increased, the capsule as well, but the drug release rates from capsules became slower. The drug release behaviors from hydroxypropyl-beta-cyclodextrin polymeric nanocapsules were affected by the drug diffusion through the polymer matrix and the formation of inclusion complex between drug and hydroxypropyl-beta-cyclodextrin. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1397 / 1402

页数：6

共 21 条

[1]

High molecular weight polyurethane and polymer hybrid particles in aqueous miniemulsion [J].