Acetyl-L-carnitine dietary supplementation to old rats increases mitochondrial transcription factor A content in rat hindlimb skeletal muscles

被引：13

作者：

Pesce, V

Fracasso, F

Musicco, C

Lezza, AMS

Cantatore, P

Gadaleta, MN

机构：

[1] Univ Bari, Dept Biochem & Mol Biol, I-70125 Bari, Italy

[2] CNR, Inst Biomembrane & Bioenerget, Bari, Italy

来源：

STRATEGIES FOR ENGINEERED NEGLIGIBLE SENESCENCE: WHY GENUINE CONTROL OF AGING MAY BE FORESEEABLE | 2004年 / 1019卷

关键词：

acetyl-L-carnitine (ALCAR); soleus; extensor digitorum longus (EDL); mitochondrial DNA (mtDNA); mitochondrial transcription factor A (TFAM);

D O I：

10.1196/annals.1297.077

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acetyl-L-carnitine (ALCAR) fed to old rats has been reported to partially restore mitochondrial function and ambulatory activity. The results of the effect of ALCAR dietary supplementation to 28-month-old rats on mitochondrial transcription factor A (TFAM) content of rat hindlimb skeletal muscles are reported.

引用

收藏

页码：430 / 433

页数：4

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