Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

被引：56

作者：

Wieronska, JM

Szewczyk, B

Branski, P

Palucha, A

Pilc, A

机构：

[1] Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland

[2] Jagiellonian Univ, Collegium Medicum, Inst Publ Hlth, Krakow, Poland

来源：

AMINO ACIDS | 2002年 / 23卷 / 1-3期

关键词：

excitatory amino acids; metabotropic glutamate receptors; mGlu5; receptors; MPEP; antidepressant effects; olfactory bulbectomy; animal models of depression;

D O I：

10.1007/s00726-001-0131-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.

引用

页码：213 / 216

页数：4

共 29 条

[1]

ALIKODJA F, 1980, BRIT J PHARMACOL, V87, P130

[2]

Bajkowska M, 1999, POL J PHARMACOL, V51, P539

[3] OLFACTORY PROJECTION SYSTEMS, DRUGS AND BEHAVIOR - REVIEW [J].