Characterization of human epigenomes

被引：113

作者：

Wang, Zhibin ^{[1
]}

Schones, Dustin E. ^{[1
]}

Zhao, Keji ^{[1
]}

机构：

[1] NHLBI, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 02期

关键词：

HISTONE ACETYLATION; DNA METHYLATION; CHROMATIN SIGNATURES; DEVELOPMENTAL REGULATORS; DYNAMIC REGULATION; GENOME; PROMOTERS; POLYCOMB; GENES; H3;

D O I：

10.1016/j.gde.2009.02.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Histone modifications play a key role in regulating transcription and thus ultimately regulate cellular development and differentiation. To understand how histone modifications influence normal development and disease states, a global catalogue of histone modifications and modifying enzymes in normal and disease states is necessary. The first such systematic mapping experiments using the recently developed ChIP-Sequencing technique have revealed a combinatorial modification 'backbone' consisting of multiple histone modifications associated with active transcription. The human epigenomic datasets that are now being produced provide valuable resources for a better understanding of the functional regulatory elements of transcription and the pathways necessary for normal cellular development and pathological conditions.

引用

页码：127 / 134

页数：8

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