Association between blocking folate receptor autoantibodies and subfertility

被引：24

作者：

Berrocal-Zaragoza, Maria Isabel ^{[1
]}

Fernandez-Ballart, Joan D. ^{[1
,2
]}

Murphy, Michelle M. ^{[1
,2
]}

Cavalle-Busquets, Pere ^{[3
]}

Sequeira, Jeffrey M. ^{[4
]}

Quadros, Edward V. ^{[4
]}

机构：

[1] Univ Rovira & Virgili, Fac Med & Ciencies Salut, Unitat Med Prevent & Salut Publ, Area Prevent Med & Publ Hlth, Tarragona, Spain

[2] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CB06 03, Madrid, Spain

[3] Hosp Univ Sant Joan, Unit Obstet & Gynaecol, Tarragona, Spain

[4] SUNY Hlth Sci Ctr, Dept Med Cell Biol, Brooklyn, NY 11203 USA

来源：

FERTILITY AND STERILITY | 2009年 / 91卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Folate receptor autoantibodies; subfertility; pregnancy; FOLIC-ACID; DEFICIENCY; PREGNANCY; RISK; HOMOCYSTEINE; AUTOIMMUNITY; REPRODUCTION; WOMEN;

D O I：

10.1016/j.fertnstert.2008.08.104

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The association between blocking folate receptor (FR) autoantibodies and subfertility was investigated in a longitudinal study of women attempting to become pregnant. Seventeen women with subfertility (failure to conceive during 12 menstrual cycles) and 25 control women (women who conceived and went on to have normal pregnancy outcomes) were studied. Subfertility risk was 12 times higher in women with blocking FR autoantibodies compared with those without (odds ratio, 12; 95% confidence interval, 1.9-129.6). (Fertil Steril (R) 2009; 91:1518-21. (C)2009 by American Society for Reproductive Medicine.)

引用

页码：1518 / 1521

页数：4