Novel RING E3 ubiquitin ligases in breast cancer

被引：73

作者：

Burger, Angelika

Amemiya, Yutaka

Kitching, Richard

Seth, Arun K.

机构：

[1] Sunnybrook Hlth Sci Ctr, Dept Pathol Anat, Lab Mol Pathol, Toronto, ON M4N 3M5, Canada

[2] Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada

[3] Univ Toronto, Dept Lab Med & Pathol, Toronto, ON, Canada

[4] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD 21201 USA

[5] Univ Maryland, Sch Med, Marlene & Stewart Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

NEOPLASIA | 2006年 / 8卷 / 08期

基金：

加拿大健康研究院;

关键词：

RING ligase; breast cancer; BCA2; RNF11; ubiquitin;

D O I：

10.1593/neo.06469

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Defects in ubiquitin E3 ligases are implicated in the pathogenesis of several human diseases, including cancer, because of their central role in the control of diverse signaling pathways. RING E3 ligases promote the ubiquitination of proteins that are essential to a variety of cellular events. Identification of which ubiquitin ligases specifically affect distinct cellular processes is essential to the development of targeted therapeutics for these diseases. Here we discuss two novel RING E3 ligases, BCA2 and RNF11, that are closely linked to human breast cancer. BCA2 E3 ligase is coregulated with estrogen receptor and plays a role in the regulation of epidermal growth factor receptor (EGF-R) trafficking. RNF11 is a small RING E3 ligase that affects transforming growth factor beta and EGF-R signaling and is overexpressed in invasive breast cancers. These two proteins demonstrate the complexity of RING E3 ligase interactions in breast cancer and are potential targets for therapeutic interventions.

引用

页码：689 / 695

页数：7

共 61 条

[1]

Amemiya A., 2005, P AM ASSOC CANC RES, V46, P2329

[2] Hrs is associated with STAM, a signal-transducing adaptor molecule - Its suppressive effect on cytokine-induced cell growth [J].