Structural and functional aspects of C1-Inhibitor

被引:49
作者
Bos, IGA
Hack, CE
Abrahams, JP
机构
[1] CLB, Dept Immunopathol, Sanquin Res, NL-1066 CX Amsterdam, Netherlands
[2] Univ Amsterdam, Acad Med Ctr, Landsteiner Lab, NL-1105 AZ Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Clin Chem, Amsterdam, Netherlands
[4] Leiden Inst Chem, Leiden, Netherlands
关键词
D O I
10.1078/0171-2985-00151
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
C1-Inh is a serpin that inhibits serine proteases from the complement and the coagulation pathway. C1-Inh consists of a serpin domain and a unique N-terminal domain and is heavily glycosylated. Nonfunctional mutants of C1-Inh can give insight into the inhibitory mechanism of C1-Inh. This review describes a novel 3D model of C1-Inh, based on a newly developed homology modelling method. This model gives insight into a possible potentiation mechanism of C1-Inh and based on this model the essential residues for efficient inhibition by C1-Inh are discussed.
引用
收藏
页码:518 / 533
页数:16
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