omega-Dialkylaminoalkyl ethers of phenyl-(5-substituted 1-phenyl-1H-pyrazol-4-yl)methanols with analgesic and anti-inflammatory activity

被引：104

作者：

Menozzi, G ^{[1
]}

Mosti, L ^{[1
]}

Fossa, P ^{[1
]}

Mattioli, F ^{[1
]}

Ghia, M ^{[1
]}

机构：

[1] UNIV GENOA,IST FARMACOL,I-16132 GENOA,ITALY

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 03期

关键词：

D O I：

10.1002/jhet.5570340339

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of carbinols 3a-f was prepared starting from methanols 1a-f via oxidation with pyridinium chlorochromate to aldehydes 2a-f, followed by a Grignard reaction of the latter. Reaction of 3a-f with omega-chloroalkyldialkylamine hydrochlorides afforded a series of aminoether derivatives 4g-t. Compounds 4i,m-p,s showed a good analgesic activity in the acetic acid writhing test in mice. Moreover, compounds 4h,l,s exhibited a moderate anti-inflammatory activity in the carrageenan-induced edema assay in rats.

引用

页码：963 / 968

页数：6

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