An autoradiographic study in μ-opioid receptor knockout mice

被引：12

作者：

Chen, HC

Seybold, VS

Loh, HH

机构：

[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 76卷 / 01期

关键词：

opioid receptor; knock-out mice; autoradiography;

D O I：

10.1016/S0169-328X(99)00346-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An autoradiographic study was carried out to study the opioid binding sites in a mu-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. mu-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional mu-opioid receptor does not affect the expression of the other two opioid receptors. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：170 / 172

页数：3

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