An autoradiographic study in μ-opioid receptor knockout mice

被引:12
作者
Chen, HC
Seybold, VS
Loh, HH
机构
[1] Univ Minnesota, Dept Pharmacol, Minneapolis, MN 55455 USA
[2] Univ Minnesota, Dept Neurosci, Minneapolis, MN 55455 USA
来源
MOLECULAR BRAIN RESEARCH | 2000年 / 76卷 / 01期
关键词
opioid receptor; knock-out mice; autoradiography;
D O I
10.1016/S0169-328X(99)00346-0
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
An autoradiographic study was carried out to study the opioid binding sites in a mu-opioid receptor knock-out mouse line whose exon 2 and 3 were deleted. mu-Opioid binding sites were undetectable in this knock-out mouse line while the binding of the other two types of receptors were unaltered. Our results suggest destroying functional mu-opioid receptor does not affect the expression of the other two opioid receptors. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:170 / 172
页数:3
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