Synthesis of a scalemic beta-amino disulfide from (S)-phenylglycine and (R)-styrene oxide and use as a catalyst in enantioselective additions of diethylzinc to aldehydes

被引：45

作者：

Fulton, DA ^{[1
]}

Gibson, CL ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PURE & APPL CHEM,GLASGOW G1 1XL,LANARK,SCOTLAND

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 11期

关键词：

D O I：

10.1016/S0040-4039(97)00221-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two routes to the novel scalemic beta-amino disulfide 7 have been developed from (S)-phenylglycine and (R)-styrene oxide. The beta-amino disulfide 7 was used as a catalyst in the enantioselective addition of diethylzinc to aldehydes providing (R)-secondary alcohols in 39-80% ee. (C) 1997 Elsevier Science Ltd.

引用

页码：2019 / 2022

页数：4

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