The Ets transcription factors of the PEA3 group: Transcriptional regulators in metastasis

被引:97
作者
de Launoit, Yvan
Baert, Jean-Luc
Chotteau-Lelievre, Anne
Monte, Didier
Coutte, Laurent
Mauen, Sebastien
Firlej, Virginie
Degerny, Cindy
Verrernan, Kathye
机构
[1] Univ Lille 1, Univ Lille 2, Inst Pasteur, CNRS,Inst Biol Lille,UMR 8161, F-59021 Lille, France
[2] Free Univ Brussels, Fac Med, Mol Virol Lab, B-1070 Brussels, Belgium
[3] Univ Paris 11, Fac Sci, Lab Biol Anim, F-91405 Orsay, France
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2006年 / 1766卷 / 01期
关键词
metastasis; transcription factor; Ets; PEA3; group; MMP;
D O I
10.1016/j.bbcan.2006.02.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:79 / 87
页数:9
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