Kinetic resolution of amines by acylation using 3-diacylaminoquinazolin-4(3H)-ones

被引：11

作者：

Al-Sehemi, AG ^{[1
]}

Atkinson, RS ^{[1
]}

Fawcett, J ^{[1
]}

Russell, DR ^{[1
]}

机构：

[1] Univ Leicester, Dept Chem, Leicester LE1 7RH, Leics, England

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 01期

关键词：

D O I：

10.1039/a907970j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four diastereoisomeric 3-diacylaminoquinazolinones 8a-d have been separated and identified by X-ray structure determinations on three of them: their stoichiometric reactions with alpha-phenylethylamine and with 2-methylpiperidine (2 equiv. of amine) gave the corresponding N-(2-acetoxypropanoyl)amine and unreacted amine in high diastereomeric/enantiomeric excess.

引用

页码：43 / 44

页数：2

共 4 条

[1] The N-N bond as a chiral axis: 3-Diacylaminoquinazolinones as chiral acylating agents [J].

Atkinson, RS ;

Barker, E ;

Edwards, PJ ;

Thomson, GA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (10) :1047-1055

[2] Diastereoselective aziridination of alkenes using 3-acetoxyamino-2-(1-hydroxyalkyl)quinazolin-4(3H)-ones in the presence of titanium(IV) tert-butoxide [J].

Atkinson, RS ;

Ayscough, AP ;

Gattrell, WT ;

Raynham, TM .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (17) :2783-2793

[3]

ATKINSON RS, 1996, CHEM COMMUN, P105

[4] The ortho-substituted N,N-diacetylaniline as a selective acetylating reagent. [J].

Murakami, Y ;

Kondo, K ;

Miki, K ;

Akiyama, Y ;

Watanabe, T ;

Yokoyama, Y .

TETRAHEDRON LETTERS, 1997, 38 (21) :3751-3754

← 1 →