A new approach to natural products discovery exemplified by the identification of sulfated nucleosides in spider venom

被引：67

作者：

Taggi, AE

Meinwald, J

Schroeder, FC ^{[1
]}

机构：

[1] Cornell Univ, Cornell Inst Res Chem Ecol, Ithaca, NY 14853 USA

[2] Cornell Univ, Dept Chem & Chem Biol, Baker Lab, Ithaca, NY 14853 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 33期

关键词：

D O I：

10.1021/ja047416n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Using a new approach based on the NMR spectroscopic analysis of the entire, unpurified spider venom, we identified a family of unusual sulfated nucleoside derivatives from the venom of the hobo spider, Tegenaria agrestis. These compounds are ribonucleoside mono- and disulfates derived from guanosine and xanthosine, some of which are glycosylated, bearing one or two D-fucose units. The use of NMR spectroscopy to characterize the unfractionated venom was central to the discovery of this heretofore overlooked class of venom components.

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页码：10364 / 10369

页数：6

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