Photodynamic therapy upregulates expression of Mac-1 and generation of leukotriene B4 by human polymorphonuclear leukocytes

被引：12

作者：

Kobayashi, W

Liu, Q

Matsumiya, T

Nakagawa, H

Yoshida, H

Imalizumi, T

Satoh, K

Kimura, H

机构：

[1] Hirosaki Univ, Sch Med, Dept Oral & Maxillofacial Surg, Hirosaki, Aomori 0368562, Japan

[2] China Med Univ, Affiliated Hosp Stomatol, Dept Oral & Maxillofacial Surg, Shenyang 110001, Peoples R China

[3] Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Vasc Biol, Hirosaki, Aomori 0368562, Japan

来源：

ORAL ONCOLOGY | 2004年 / 40卷 / 05期

关键词：

photodynamic therapy; mono-L-aspartyl chlorine 6; polymorphonuclear leukocytes; Mac-1; leukotriene B-4;

D O I：

10.1016/j.oraloncology.2003.10.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This study investigated the expression of Mac-1 (CD11b/CD18) and generation of leukotriene B-4 (LTB4) by polymorphonuclear leukocytes (PMNs) in response to Mono-L-aspartyl chlorine 6 (NPe6) mediated photodynamic therapy (PDT). PDT was carried out using a laser diode at a light dose of 10 J/cm(2) and wavelength of 664 nm. Expression of Mac-1 was significantly increased about 3-fold by PDT compared with that of Npe6 exposure. The increase in the expression of Mac-1 was not inhibited by 5-lipoxygenase inhibitor (AA861). On the other hand, generation of LTB4 by PMNs was increased by incubation with NPe6 atone and further promoted by PDT and that was significantly inhibited by AA861. These results suggest that PDT can induce PMNs to express extensively Mac-1 and generate a certain amount of LTB4 that may play an important cytocidal. rote in the treatment of oral cancer. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：506 / 510

页数：5

共 23 条

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A NOVEL MECHANISM FOR THE GENERATION OF SUPEROXIDE ANIONS IN HEMATOPORPHYRIN DERIVATIVE MEDIATED CUTANEOUS PHOTOSENSITIZATION - ACTIVATION OF THE XANTHINE-OXIDASE PATHWAY [J].