Potentiation of myoblast transplantation by host muscle irradiation is dependent on the rate of radiation delivery

被引：30

作者：

Gross, JG ^{[1
]}

Bou-Gharios, G ^{[1
]}

Morgan, JE ^{[1
]}

机构：

[1] Hammersmith Hosp, Imperial Coll Sch Med, MRC, Ctr Clin Sci, London W12 0NN, England

来源：

CELL AND TISSUE RESEARCH | 1999年 / 298卷 / 02期

基金：

英国医学研究理事会;

关键词：

radiation; myoblast transplantation therapy; muscle regeneration; mouse (mdx nu/nu);

D O I：

10.1007/s004419900062

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transplantation of muscle precursor cells (mpc) has been suggested as a treatment for myopathies, such as Duchenne muscular dystrophy. Irradiation of skeletal muscle with 16-20 Gy prevents muscle regeneration and also augments muscle formation from implanted muscle precursor cells (mpc). However, when mdx nu/nu mouse muscles are preirradiated at 0.73 Gy/min rather than at 1.29 Gy/min prior to their injection with normal mpc, significantly more muscle fibres of donor origin are formed. This suggests that the rate at which irradiation is delivered has a physiological effect on the muscle. Although it would not be feasible to irradiate a patient's muscles prior to mpc implantation, once the factor(s) which are altered in irradiated muscle have been identified, it might be possible to use these to increase the success of myoblast transplantation.

引用

页码：371 / 375

页数：5

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