Enantioselective Artificial Metalloenzymes Based on a Bovine Pancreatic Polypeptide Scaffold

被引：78

作者：

Coquiere, David ^{[1
]}

Bos, Jeffrey ^{[1
]}

Beld, Joris ^{[2
]}

Roelfes, Gerard ^{[1
]}

机构：

[1] Univ Groningen, Stratingh Inst Chem, NL-9747 AG Groningen, Netherlands

[2] ETH, Organ Chem Lab, Honggerberg HCI, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 28期

关键词：

artificial metalloenzymes; asymmetric catalysis; copper; Diels-Alder reactions; Michael addition; ALPHA; BETA-UNSATURATED 2-ACYL IMIDAZOLES; ASYMMETRIC CATALYSIS; OXALOACETATE DECARBOXYLASE; TRIFLATE COMPLEXES; DIRECTED EVOLUTION; HYBRID CATALYSTS; BIOTIN-AVIDIN; DESIGN; PROTEIN; PEPTIDE;

D O I：

10.1002/anie.200901134

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Site creation: Enantioselective artificial metalloenzymes have been created by grafting a new active site onto bovine pancreatic polypeptide through the introduction of an amino acid capable of coordinating a copper(II) ion. This hybrid catalyst gave good enantioselectivities in the Diels- Alder and Michael addition reactions in water (see scheme) and displayed a very high substrate selectivity. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5159 / 5162

页数：4

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