Effects of FTY720, a novel immunosuppressant, on experimental autoimmune uveoretinitis in rats

被引：50

作者：

Kurose, S

Ikeda, E

Tokiwa, M

Hikita, N

Mochizuki, M

机构：

[1] Kurume Univ, Sch Med, Dept Ophthalmol, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ Hosp, Clin Lab, Kurume, Fukuoka, Japan

[3] Tokyo Med & Dent Univ, Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo 113, Japan

来源：

EXPERIMENTAL EYE RESEARCH | 2000年 / 70卷 / 01期

关键词：

FTY720; immunosuppressant; experimental autoimmune uveoretinitis; retinal S-antigen; rats;

D O I：

10.1006/exer.1999.0777

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The immunosuppressive properties of FTY720, a novel immunosuppressant obtained by structural modification of ISP-I isolated from the fermentation broth of Isaria sinclairii, were studied in experimental autoimmune uveoretinitis (EAU) in rats. Lewis rats were immunized with S-antigen and treated with FTY720 (0.03, 0.06, 0.1 mg kg(-1) day(-1)) or distilled water for 16 days after the immunization. FTY720 suppressed the incidence and intensity of EAU in a dose-dependent manner as demonstrated by clinical and histological examinations. The drug significantly suppressed the serum levels of antibodies to Santigen and antigens-specific lymphocyte proliferation. The number of peripheral lymphocytes, but not neutrophils, was markedly reduced by FTY720 treatment. FTY720 also suppressed the intensity of EAU when it was given from the day of EAU onset. These results indicate that FTY720 has intense immunosuppressive effects on EAU in rats and may be a potential candidate for use in the treatment of patients with autoimmune uveitis. (C) 2000 Academic Press.

引用

页码：7 / 15

页数：9

共 21 条

[11] Kawaguchi T, 1996, TRANSPLANT P, V28, P1062
[12] KAWASHIMA H, 1988, INVEST OPHTH VIS SCI, V29, P1265
[13] Masubuchi Y, 1996, TRANSPLANT P, V28, P1064
[14] MOCHIZUKI M, 1985, INVEST OPHTH VIS SCI, V26, P226
[15] EFFECTS OF FK506, 15-DEOXYSPERGUALIN, AND CYCLOSPORINE ON EXPERIMENTAL AUTOIMMUNE UVEORETINITIS IN THE RAT
MOCHIZUKI, M
KAWASHIMA, H
[J]. AUTOIMMUNITY, 1990, 8 (01) : 37 - 41
[16] EFFECTS OF BUCILLAMINE, A NEW ANTIRHEUMATIC DRUG, ON THE EXPERIMENTAL AUTOIMMUNE UVEITIS IN RATS
SAWA, K
MOCHIZUKI, M
[J]. EXPERIMENTAL EYE RESEARCH, 1994, 58 (04) : 431 - 438
[17] Suzuki S, 1996, TRANSPLANT P, V28, P1375
[18] Suzuki S, 1996, Transpl Immunol, V4, P252, DOI 10.1016/S0966-3274(96)80026-8
[19] A novel immunosuppressant, FTY720, with a unique mechanism of action, induces long-term graft acceptance in rat and dog allotransplantation
Suzuki, S
Enosawa, S
Kakefuda, T
Shinomiya, T
Amari, M
Naoe, S
Hoshino, Y
Chiba, K
[J]. TRANSPLANTATION, 1996, 61 (02) : 200 - 205
[20] Suzuki S, 1996, TRANSPLANT P, V28, P2049

← 1 2 3 →