Learning Tolerance while Fighting Ignorance

被引：118

作者：

Sansonetti, Philippe J. ^{[1
,2
]}

Medzhitov, Ruslan ^{[3
,4
]}

机构：

[1] Inst Pasteur, Unite Pathogenie Microbienne Mol, F-75724 Paris 15, France

[2] Coll France, F-75231 Paris 05, France

[3] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

[4] Yale Univ, Dept Immunobiol, Sch Med, New Haven, CT 06510 USA

来源：

CELL | 2009年 / 138卷 / 03期

关键词：

INTESTINAL IMMUNE HOMEOSTASIS; NF-KAPPA-B; EPITHELIAL-CELLS; INNATE IMMUNITY; GENE-EXPRESSION; INFLAMMATION; GUT; DISEASE; MICROBIOTA; BACTERIA;

D O I：

10.1016/j.cell.2009.07.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Research on microbe-host interactions focuses principally on pathogens, yet our immune system must deal with the huge number of beneficial commensal bacteria in our gut. It is becoming clear that the host immune system must reach a delicate balance between destroying dangerous bacterial pathogens while preserving the beneficial gut microbiota.

引用

收藏

页码：416 / 420

页数：5

相关论文

共 33 条

[1] TLR signaling in the gut in health and disease [J].

Abreu, MT ;

Fukata, M ;

Arditi, M .

JOURNAL OF IMMUNOLOGY, 2005, 174 (08) :4453-4460

[2] Innate and adaptive immune responses related to IBD pathogenesis [J].

Arseneau K.O. ;

Tamagawa H. ;

Pizarro T.T. ;

Cominelli F. .

Current Gastroenterology Reports, 2007, 9 (6) :508-512

[3] Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota [J].

Bates, Jennifer M. ;

Akerlund, Janie ;

Mittge, Erika ;

Guillemin, Karen .

CELL HOST & MICROBE, 2007, 2 (06) :371-382

[4] Antagonistic lipopolysaccharides block E-coli lipopolysaccharide function at human TLR4 via interaction with the human MD-2 lipopolysaccharide binding site [J].

Coats, Stephen R. ;

Do, Christopher T. ;

Karimi-Naser, Lisa M. ;

Braham, Pamela H. ;

Darveau, Richard P. .

CELLULAR MICROBIOLOGY, 2007, 9 (05) :1191-1202

[5] Cutting edge: Bacterial modulation of epithelial signaling via changes in neddylation of cullin-1 [J].

Collier-Hyams, LS ;

Sloane, V ;

Batten, BC ;

Neish, AS .

JOURNAL OF IMMUNOLOGY, 2005, 175 (07) :4194-4198

[6] Gastrointestinal microbiology enters the metagenomics era [J].

Frank, Daniel N. ;

Pace, Norman R. .

CURRENT OPINION IN GASTROENTEROLOGY, 2008, 24 (01) :4-10

[7] The Bacillus subtilis quorum-sensing molecule CSF contributes to intestinal Homeostasis via OCTN2, a host cell membrane transporter [J].

Fujiya, Mikihiro ;

Musch, Mark W. ;

Nakagawa, Yasushi ;

Hu, Shien ;

Alverdy, John ;

Kohgo, Yutaka ;

Schneewind, Olaf ;

Jabri, Bana ;

Chang, Eugene B. .

CELL HOST & MICROBE, 2007, 1 (04) :299-308

[8] Analysis of the genome structure of the nonpathogenic probiotic Escherichia coli strain Nissle 1917 [J].

Grozdanov, L ;

Raasch, C ;

Schulze, E ;

Sonnenborn, U ;

Gottschalk, G ;

Hacker, J ;

Dobrindt, U .

JOURNAL OF BACTERIOLOGY, 2004, 186 (16) :5432-5441

[9] Animal models of inflammatory bowel disease:: An overview [J].

Hoffmann, JC ;

Pawlowski, NN ;

Kühl, AA ;

Höhne, W ;

Zeitz, M .

PATHOBIOLOGY, 2002, 70 (03) :121-130

[10] Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation [J].

Izcue, Ana ;

Coombes, Janine L. ;

Powrie, Fiona .

IMMUNOLOGICAL REVIEWS, 2006, 212 :256-271

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