Prognostic significance of hTERT expression in non-small cell lung cancer

被引：8

作者：

Komiya, T

Kawase, I

Nitta, T

Yasumitsu, T

Kikui, M

Fukuoka, M

Nakagawa, K

Hirashima, T

机构：

[1] Kinki Univ, Sch Med, Dept Internal Med 4, Osaka 5898511, Japan

[2] Osaka Prefectural Habikino Hosp, Dept Internal Med, Habikino, Osaka 5838588, Japan

[3] Osaka Prefectural Habikino Hosp, Dept Surg, Habikino, Osaka 5838588, Japan

[4] Osaka Prefectural Habikino Hosp, Dept Pathol, Habikino, Osaka 5838588, Japan

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2000年 / 16卷 / 06期

关键词：

telomerase; telomere;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

To investigate the prognostic role of hTERT expression in non-small cell lung cancer (NSCLC), we examined the expression of hTERT mRNA in tumor specimens from 68 patients with NSCLC using RT-PCR. The expression of hTERT was detected in 34 (50%) of 68 cancer tissues. There were no correlations between hTERT status and any common clinical features except age. Patients with hTERT expression had shorter survival than those without hTERT expression. Multivariate analysis showed that hTERT expression was an independent negative prognostic factor. These results suggest that expression of hTERT may be an independent prognostic factor for NSCLC patients.

引用

页码：1173 / 1177

页数：5

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