Regulation of TRP channels by phosphorylation

被引：58

作者：

Yao, Xiaoqiang ^{[1
]}

Kwan, Hiu-Yee ^{[1
]}

Huang, Yu ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Dept Physiol, Hong Kong, Hong Kong, Peoples R China

来源：

NEUROSIGNALS | 2005年 / 14卷 / 06期

关键词：

TRP channels; phosphorylation; Ca2+ influx;

D O I：

10.1159/000093042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The transient receptor potential (TRP) channels are a group of Ca2+-permeable cation channels (except TRPM4 and TRPM5) that function as cellular sensors of various internal and external stimuli. Most of these channels are expressed in the nervous system and they play a key role in sensory physiology. They may respond to temperature, pressure, inflammatory agents, pain, osmolarity, taste and many other stimuli. Recent development indicates that the activity of these channels is regulated by protein phosphorylation and dephosphorylation of serine, threonine, and tyrosine residues. In this review, we present a comprehensive summary of the literature regarding the TRP channel regulation by different protein kinases.

引用

页码：273 / 280

页数：8

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