Current status of research on osteoporosis in COPD: a systematic review

被引：196

作者：

Graat-Verboom, L. ^{[1
,2
]}

Wouters, E. F. M. ^{[1
,3
]}

Smeenk, F. W. J. M. ^{[2
]}

van den Borne, B. E. E. M. ^{[2
]}

Lunde, R. ^{[4
]}

Spruit, M. A. ^{[3
]}

机构：

[1] Maastricht Univ, Med Ctr, Dept Resp Med, NL-6229 HX Maastricht, Netherlands

[2] Catharina Hosp, Dept Resp Med, Eindhoven, Netherlands

[3] Ctr Integrated Rehabil Organ Failure, Dept Res Dev & Educ, Horn, Netherlands

[4] St Jan Hosp, Dept Resp Med, Weert, Netherlands

来源：

EUROPEAN RESPIRATORY JOURNAL | 2009年 / 34卷 / 01期

关键词：

Bone loss; bone mineral density; chronic obstructive pulmonary disease; pharmacotherapy; systemic effects; OBSTRUCTIVE PULMONARY-DISEASE; BONE-MINERAL DENSITY; LUNG-TRANSPLANT RECIPIENTS; FAT-FREE MASS; POSTMENOPAUSAL WOMEN; RESPIRATORY-FUNCTION; RANDOMIZED-TRIAL; BODY-COMPOSITION; ASSOCIATION; ALENDRONATE;

D O I：

10.1183/09031936.50130408

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Patients with chronic obstructive pulmonary disease (COPD) are at increased risk of osteoporosis. However, the prevalence, correlates and effectiveness of treatment of osteoporosis in COPD patients remain unclear. We performed a systematic review of the literature to answer three questions. 1) What is the prevalence of osteoporosis in COPD? 2) What are identified correlates of osteoporosis in COPD? 3) What are the effects of treatment of osteoporosis in COPD? A computerised literature search in MEDLINE/PubMed and the Cochrane database was carried out. In addition, reference lists were searched by hand and authors were contacted if necessary. The prevalence of osteoporosis and osteopenia varied 9-69% and 27-67%, respectively. Prevalence of osteoporosis was generally higher than in healthy subjects and some other chronic lung diseases. Correlates of osteoporosis in COPD are mainly measures of body composition, disease severity and the use of corticosteroids, although causality has not been proven. Effects of treatment of osteoporosis have not been investigated in samples consisting of COPD patients only. Longitudinal follow-up to assess determinants of osteoporosis in COPD and randomised placebo-controlled trials on the effects of treatment of osteoporosis in patients with COPD only are warranted.

引用

页码：209 / 218

页数：10

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