How DCs control cross-regulation between lymphocytes

被引：13

作者：

Creusot, RJ

Mitchison, NA

机构：

[1] Stanford Univ, Dept Med, Sch Med, Div Rheumatol & Immunol, Stanford, CA 94305 USA

[2] UCL, Windeyer Inst Med Sci, Dept Immunol & Mol Pathol, London W1T 4JF, England

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 03期

关键词：

D O I：

10.1016/j.it.2004.01.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dendritic cells (DCs) acquire and present a variety of antigens from a given pathogen. They orchestrate the development of the immune response by integrating and relaying various signals through interactions with T, B, natural killer (NK) and NKT cells. Owing to compartmentalization of these different cell types, sequential interactions often take place, for example, when innate immunity influences adaptive immunity. Lymphocytes within the DC cluster can instruct each other indirectly, by fine tuning of DC function, or directly, by local cytokine secretion, with presumably more pronounced effects when the interactions are concomitant rather than sequential and when the T cells are experienced. Moreover, DCs also shape the immune repertoire according to the frequency and antigen specificity of the responding lymphocytes they recruit.

引用

页码：126 / 131

页数：6

共 64 条

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