Expression of Golli proteins in adult human brain and multiple sclerosis lesions

被引:26
作者
Filipovic, R [1 ]
Rakic, S [1 ]
Zecevic, N [1 ]
机构
[1] Univ Connecticut, Sch Med, Dept Neurosci, Farmington, CT 06030 USA
关键词
Golli; chronic MS; autoimmune disease; oligodendrocyte progenitors; microglia/macrophages;
D O I
10.1016/S0165-5728(02)00070-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
It has been suggested that Golli proteins, structurally related to myelin basic proteins (MBPs), have a role in autoimmune processes. We studied the expression of these proteins in multiple sclerosis (MS) and determined that the number of Golli-immunoreactive (ir) cells was significantly higher around lesions of chronic MS than in control white matter. Golli proteins were expressed in the adult oligodendrocyte precursor cells (OPCs), activated microglia/macrophages, and some demyelinated axons around MS lesions. Their expression in adult OPCs indicates remyelination attempts, whereas the expression in the subpopulation of microglia/macrophages suggests roles in the immune processes of MS. In addition, Golli proteins may be markers of axonal transection, which is characteristic for MS. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:1 / 12
页数:12
相关论文
共 90 条
  • [71] Robinson S, 1998, J NEUROSCI, V18, P10457
  • [72] Contact with central nervous system myelin inhibits oligodendrocyte progenitor maturation
    Robinson, S
    Miller, RH
    [J]. DEVELOPMENTAL BIOLOGY, 1999, 216 (01) : 359 - 368
  • [73] Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
    Scolding, N
    Franklin, R
    Stevens, S
    Heldin, CH
    Compston, A
    Newcombe, J
    [J]. BRAIN, 1998, 121 : 2221 - 2228
  • [74] Shi JY, 1998, J NEUROSCI, V18, P4627
  • [75] Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    Steinman, L
    [J]. CELL, 1996, 85 (03) : 299 - 302
  • [76] MONOCLONAL-ANTIBODIES DISTINGUISH PHOSPHORYLATED AND NONPHOSPHORYLATED FORMS OF NEUROFILAMENTS INSITU
    STERNBERGER, LA
    STERNBERGER, NH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (19): : 6126 - 6130
  • [77] Identification of Golli and myelin basic proteins in human brain during early development
    Tosic, M
    Rakic, S
    Matthieu, JM
    Zecevic, N
    [J]. GLIA, 2002, 37 (03) : 219 - 228
  • [78] Tranquill LR, 1996, J NEUROSCI RES, V45, P820, DOI 10.1002/(SICI)1097-4547(19960915)45:6<820::AID-JNR19>3.0.CO
  • [79] 2-Z
  • [80] Neurodegeneration in multiple sclerosis, relationship to neurological disability
    Trapp, BD
    Ransohoff, RM
    Fisher, E
    Rudick, RA
    [J]. NEUROSCIENTIST, 1999, 5 (01) : 48 - 57