Increased sensitivity to ET-I in rat cerebral arteries following organ culture

被引：30

作者：

Hansen-Schwartz, J ^{[1
]}

Edvinsson, L ^{[1
]}

机构：

[1] Univ Copenhagen, Glostrup Hosp, Dept Clin Expt Res, DK-2600 Glostrup, Denmark

来源：

NEUROREPORT | 2000年 / 11卷 / 03期

关键词：

endothelin; ETA/ETB receptor; organ culture; potency; SAH; stroke;

D O I：

10.1097/00001756-200002280-00042

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible pathological changes we studied changes in ETA and ETB receptor function using a sensitive in vitro method. We observed an up-regulation of the ETB receptor and an amazingly increased sensitivity to ET-1 by 3 log units in pEC(50); pEC(50(fresh)) was 8.7 +/- 0.1, and pEC(50(cultured)) was 11.7 +/- 0.3, pA(2) for FR139317 in the fresh vessel was 7.0 +/- 0.2 whereas it could not be obtained for the cultured vessel, indicating a possible cross-talk between the ETA and ETB receptors. The increased sensitivity to ET-1 could also take place during cerebrovascular disease such:as stroke or haemorrhage rendering the vessels considerably more sensitive to ET-1. NeuroReport 11:649-652 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：649 / 652

页数：4

共 20 条

[11] Transcriptional regulated plasticity of vascular contractile endothelin ETB receptors after organ culture [J].