Pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection

被引：29

作者：

Hisatomi, Toshio ^{[1
,2
]}

Ishibashi, Tatsuro

Miller, Joan W. ^{[2
]}

Kroemer, Guido ^{[3
,4
,5
]}

机构：

[1] Kyushu Univ, Dept Ophthalmol, Grad Sch Med Sci, Higashi Ku, Fukuoka 8128582, Japan

[2] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol,Angiogenesis Lab, Boston, MA USA

[3] INSERM, U848, Villejuif, France

[4] Inst Gustave Roussy, Villejuif, France

[5] Univ Paris 11, Villejuif, France

来源：

EXPERIMENTAL NEUROLOGY | 2009年 / 218卷 / 02期

关键词：

Apoptosis; Mitochondria membrane permeabilization; Caspase; AIF; Apaf-1; Cytochrome c; Retina; APOPTOSIS-INDUCING FACTOR; HIV PROTEASE INHIBITORS; ISCHEMIC BRAIN-INJURY; ADENINE-NUCLEOTIDE TRANSLOCATOR; NEURONAL CELL-DEATH; IN-VIVO; NEUROTROPHIC FACTOR; INNER MEMBRANE; 1-METHYL-4-PHENYLPYRIDINIUM TOXICITY; PHOTORECEPTOR APOPTOSIS;

D O I：

10.1016/j.expneurol.2009.03.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent data have provided important clues about the molecular mechanisms underlying certain neurodegenerative diseases. Most cell death in vertebrates proceeds via the mitochondrial pathway of apoptosis. Mitochondria contain proapoptotic factors such as cytochrome c and AIF in their intermembrane space. Furthermore, mitochondrial membrane permeabilization (MMP) is a critical event during apoptosis, representing the "point of no return" of the lethal process. Modern medicine is developing an increasing number of drugs for neurodegenerative disease, but no neuroprotective treatment has yet been established. While current treatments temporarily alleviate symptoms, they do not halt disease progression. This paper briefly reviews the pharmacological inhibition of mitochondrial membrane permeabilization for neuroprotection. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：347 / 352

页数：6

共 83 条

[81] Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat [J].