Nobilisides A-C, three new triterpene glycosides from the sea cucumber Holothuria nobilis

被引：38

作者：

Wu, Jun

Yi, Yang-Hua

Tang, Hai-Feng

Wu, Hou-Ming

Zou, Zhen-Rong

Lin, Hou-Wen

机构：

[1] Second Mil Med Univ, Coll Pharm, Res Ctr Marine Drugs, Shanghai 200433, Peoples R China

[2] Fourth Mil Med Univ, Dept Pharm, Xijing Hosp, Xian 710032, Peoples R China

[3] Chinese Acad Sci, State Key Lab Bioorgan & Nat Prod Chem, Shanghai Inst Organ Chem, Shanghai, Peoples R China

[4] Changzheng Hosp, Dept Pharm, Shanghai, Peoples R China

来源：

PLANTA MEDICA | 2006年 / 72卷 / 10期

关键词：

D O I：

10.1055/s-2006-931603

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Three new triterpene glycosides, named nobilisides A (1), B (2) and C (3), were isolated from the sea cucumber Holothuria nobilis Selenka. Their structures were deduced by extensive spectral analysis and chemical evidence. Compounds 1 and 3 are non-sulfated monoglycosides while 2 is a sulfated diglycoside. The presence of two conjugated double bonds [22E,24-diene and 7,9(11)-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides, while 2 and 3 possess the same 22,25-epoxy moiety as their side chains., All three glycosides exhibited significant cytotoxicity against human tumor cell lines.

引用

页码：932 / 935

页数：4

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